Our understanding of AAV is increasing

AAV (ANCA-associated vasculitis) is a group of progressive, rare, and severe autoimmune diseases.^1,2

AAV can affect blood vessels in different parts of the body resulting in damage to vital organs such as the lungs, kidneys, nervous system, gastrointestinal system, skin, eyes, and heart.²

The three main clinical subtypes of AAV are GPA (granulomatosis with polyangiitis, previously called Wegener’s), MPA (microscopic polyangiitis) and EGPA (eosinophilic granulomatosis with polyangiitis, previously called Churg-Strauss syndrome).^3,4 Both GPA and MPA show a lot of clinical commonality, whereas EGPA is distinctly different.⁵ For this reason, this website will focus mainly on GPA and MPA.

References & footnotes

Discover the key clinical data in AAV

Our current understanding of patient outcomes in ANCA-associated vasculitis (AAV) is rapidly evolving as more studies are being conducted.

Click here to read the key clinical research papers to find out more about treatment outcomes in AAV.

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AAV mechanism of disease

See how the interaction between neutrophils and the alternative complement system are at the heart of the vasculitis process in AAV.

More information

EULAR 2022 recommendations

Download our infographic to view the latest updates and recommendations from EULAR around the treatment of AAV.

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Helpful resources

Use our interactive educational tools to discover more about ANCA-associated vasculitis (AAV).

AAV World is an educational game that sheds light on the clinical priorities in AAV in a fun and interactive way. Take part in AAV World and test your skills through a mix of challenges, brainteasers, riddles and quizzes. Or why not join the Rare Disease Investigation Team and put your expertise to the test in our mysterious challenge.

Complete the challenges